Drug Desensitization

Drug desensitization is a process in which a drug to which the patient is allergic is administered to the patient in small, incremental doses to induce a state of temporary tolerance to the drug. This should only be attempted if the offending drug is deemed essential and no alternatives are available. This treatment has been well established for IgE-mediated drug allergy, specifically to penicillins.

Drug desensitization for non–IgE-mediated drug allergy has also been described for various drugs. Although treatment has been shown to be effective, the underlying mechanisms for its success remain unknown.

Drug Desensitization 1

In some situations, rapid desensitization in a few hours may be required.  In addition, desensitization over a period of days to weeks may be acceptable if the need is for prophylaxis or more chronic treatment. Desensitization via the oral route may be safer than by the IV (parenteral) route, but the process is dependent on adequate absorption and may be complicated by vomiting. A beginning dose can be selected as a fraction, possibly 1/100 or 1/1000 of the subject ’s known tolerance of the agent or by arbitrarily starting with 1:1000 to 1:10,000 dilution of the therapeutic concentration. Subsequent doses are then increased by doubling. After the therapeutic concentration (dose) is reached, the patient should continue to receive the agent.

Induction of tolerance to the offending drug is temporary and patients are still regarded as allergic to that particular drug. Should the patient require the medication 3-7 days after stopping desensitization, then the process should be reinstituted.

Desensitization protocols have been described for many drugs including penicillins, cephalosporins, Cotrimoxazole, Allopurinol, and chemotherapeutic agents.

Drug Allergy & Desensitization Treatment in Los Angeles | Drug Desensitization Therapy & Drug Allergy Clinic Los Angeles

If you’re in Los Angeles and seeking expert care for drug allergies and desensitization treatment, look no further than Asif Rafi, MD. Dr. Asif Rafi is a leading specialist in the field of drug allergy and desensitization therapy, offering comprehensive services at his state-of-the-art clinic in Los Angeles. Drug allergies can range from mild skin rashes to life-threatening anaphylactic reactions. Dr. Rafi’s extensive experience in diagnosing and treating drug allergies allows patients to find relief and peace of mind. He employs advanced diagnostic techniques and personalized treatment plans to address each patient’s unique needs.

One of Dr. Rafi’s primary areas of expertise is drug desensitization therapy. This innovative treatment approach is especially beneficial for individuals who have experienced severe allergic reactions to medications they require for their health. Under Dr. Rafi’s care, patients can gradually build up their tolerance to the drug, reducing the risk of adverse reactions. At the Drug Allergy Clinic Los Angeles, patients can expect compassionate and patient-centered care from a highly respected medical professional. Dr. Asif Rafi’s dedication to improving the lives of individuals with drug allergies sets him apart as a leading expert in Los Angeles. If you or a loved one is in need of drug allergy or desensitization treatment, Dr. Rafi is the trusted physician you can count on for specialized care and peace of mind.